研究業績 | 斉藤研究室 Saito Lab.

〈2013年以降抜粋〉

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test throughdifferent neuronal circuits in mice. Wulaer B, Kunisawa K, Tanabe M, Yanagawa A, Saito K, Mouri A, Nabeshima T.Mol Brain. Feb 28;14(1):43. doi:10.1186/s13041-021-00760-3. PMID: 33640003; PMCID: PMC7916264. (2021).

Mutual stain conversion between Giemsa andPapanicolaou in cytological images using cycle generative adversarial network.Heliyon. Teramoto A, Yamada A, Tsukamoto T, Kiriyama Y, Sakurai E, Shiogama K, MichibaA, Imaizumi K, Saito K, Fujita H. Feb 24;7(2):e06331. doi: 10.1016/j.heliyon.2021.e06331. PMID:33718644; PMCID: PMC7921513. (2021).

Kynurenine 3-monooxygenase deficiency inducesdepression-like behavior via enhanced antagonism of α7 nicotinic acetylcholinereceptors by kynurenic acid. Mori Y, Mouri A, Kunisawa K, Hirakawa M, Kubota H, Kosuge A, Niijima M,Hasegawa M, Kurahashi H, Murakami R, Hoshi M, Nakano T, Fujigaki S, Fujigaki H,Yamamoto Y, Nabeshima T, Saito K. Behav Brain Res. Feb 16;405:113191. doi:10.1016/j.bbr.2021.113191. Epub ahead of print. PMID: 33607168. (2021).

Synthetic CT image generation of shape-controlled lung cancer using semi-conditional InfoGAN and its applicability for type classification. Toda R, Teramoto A, Tsujimoto M, Toyama H, Imaizumi K, Saito K, Fujita H. Int J ComputAssist Radiol Surg. Feb;16(2):241-251. (2021).

Progranulin depletion inhibits proliferation via the transforminggrowth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells. Yabe K, Yamamoto Y, Takemura M, Hara T, Tsurumi H, Serrero G, Nabeshima T,Saito K. Heliyon. Jan 8;7(1):e05849. doi: 10.1016/j.heliyon.2020.e05849. PMID:33490663; PMCID: PMC7809376, (2021).

Prefrontal cortex, dorsomedial striatum, and dentate gyrus are necessary in theobject-based attention test in mice. Wulaer B, Kunisawa K, Kubota H, Suento WJ, Saito K, Mouri A, Nabeshima T. Mol Brain. Dec 14;13(1):171. doi:10.1186/s13041-020-00711-4. PMID: 33317607; PMCID: PMC7737308. (2020).

Prefrontal cortexmiR-874-3p prevents lipopolysaccharide-induced depression-like behavior throughinhibition of indoleamine 2,3-dioxygenase 1 expression in mice. Suento WJ, Kunisawa K, Wulaer B, Kosuge A, Iida T, Fujigaki S, Fujigaki H,Yamamoto Y, Tanra AJ, Saito K, Mouri A, Nabeshima T. J Neurochem. Oct 23. doi: 10.1111/jnc.15222. Epub ahead of print. PMID: 33095942. (2020).

Virtual digital subtractionangiography using multizone patch-based U-Net. Kimura R, Teramoto A, Ohno T, Saito K, Fujita H. Phys Eng Sci Med. 2020Dec;43(4):1305-1315. doi: 10.1007/s13246-020-00933-9. Epub Oct 7. PMID:33026591. (2020).

Reliability of serological tests forCOVID-19: comparison of three immunochromatography test kits for SARS-CoV-2antibodies. Fujigaki H, Takemura M, Osawa M, Sakurai A, Nakamoto K, Seto K, Fujita T,Hata T, Akiyama H, Doi Y, Saito K. Heliyon. Sep 10;6(9):e04929. doi:10.1016/j.heliyon.2020.e04929. PMID: 32984615; PMCID: PMC7495099. (2020).

Indoleamine2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-LikeSkin Inflammation. Fujii K, Yamamoto Y, Mizutani Y, Saito K, Seishima M. Int J Mol Sci. Aug 1;21(15):5515. doi:10.3390/ijms21155515. PMID: 32752186; PMCID: PMC7432009. (2020).

QTVariability Index is Correlated with Autonomic Nerve Activity in HealthyChildren. Kusuki H, Tsuchiya Y, Mizutani Y, Nishio M, Oikawa S, Nagata R, KiriyanagiY, Horio K, Kojima A, Uchida H, Kojima N, Saito K, Sadanaga T, Hata T. Pediatr Cardiol. Oct;41(7):1432-1437. (2020).

Investigation of pulmonary nodule classification using multi-scaleresidual network enhanced with 3DGAN-synthesized volumes. Onishi Y, Teramoto A, Tsujimoto M, Tsukamoto T, Saito K, Toyama H, ImaizumiK, Fujita H. Radiol Phys Technol.2020 Jun;13(2):160-169. (2020).

Lithium attenuates d-amphetamine-inducedhyperlocomotor activity in mice via inhibition of interaction betweencyclooxygenase-2 and indoleamine-2,3-dioxygenase. Phan DH, Shin EJ, Jeong JH, Tran HQ, Sharma N, Nguyen BT, Jung TW, Nah SY,Saito K, Nabeshima T, Kim HC. Clin Exp Pharmacol Physiol. May;47(5):790-797. (2020).

Kynurenine produced by indoleamine 2,3-dioxygenase 2 exacerbates acute liver injury by carbon tetrachloride in mice., Hoshi M, Osawa Y, Nakamoto K, Morita N, Yamamoto Y, Ando T, Tashita C, Nabeshima T, Saito K. Toxicology , 438, 152458-152458, (2020).

Wulaer B, Kunisawa K, Hada K, Suento W J, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T: Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus., Journal of neurochemistry. Apr 10. doi: 10.1111/jnc.15022. (2020).

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. Tashita C, Hoshi M, Hirata A, Nakamoto K, Ando T, Hattori T, Yamamoto Y, Tezuka H, Tomita H, Hara A, Saito K. World journal of gastroenterology , 26(9), 918-932, (2020).

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder., Sakurai M, Yamamoto Y, Kanayama N, Hasegawa M, Mouri A, Takemura M, Matsunami H, Miyauchi T, Tokura T, Kimura H, Ito M, Umemura E, Boku A S, Nagashima W, Tonoike T, Kurita K, Ozaki N, Nabeshima T, Saito K. Scientific reports , 10(1), 1961-1961, (2020).

Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression., Lu Q, Mouri A, Yang Y, Kunisawa K, Teshigawara T, Hirakawa M, Mori Y, Yamamoto Y, Libo Z, Nabeshima T, Saito K. Behavioural brain research , 372, 112053-112053, (2019).

Indoleamine 2,3-dioxygenase 2 depletion suppresses tumor growth in a mouse model of Lewis lung carcinoma., Yamasuge W, Yamamoto Y, Fujigaki H, Hoshi M, Nakamoto K, Kunisawa K, Mouri A, Nabeshima T, Saito K. Cancer science , 110(10), 3061-3067, (2019).

Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker., Murakami Y, Imamura Y, Saito K, Sakai D, Motyama J. Scientific reports , 9(1), 13182-13182, (2019).

Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues., Yoshida Y, Fujigaki H, Kato K, Yamazaki K, Fujigaki S, Kunisawa K, Yamamoto Y, Mouri A, Oda A, Nabeshima T, Saito K. Scientific reports , 9(1), 10243-10243, (2019).

Teshigawara T,Mouri A,Kubo H,Nakamura Y,Shiino T,Okada T,Morikawa M,Nabeshima T,Ozaki N,Yamamoto Y,Saito K: Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms., Journal of affective disorders , 255, 168-176, (2019).

5-HT1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKC delta and p47phox. Tran, H. Q., Shin, E. J., Hoai Nguyen, B. C., Phan, D. H., Kang, M.J., Jang, C. G., Jeong, J. H., Nah, S. Y., Mouri, A., Saito, K., Nabeshima,T., and Kim, H. C. Food Chem Toxicol 123, 125-141 (2019)

Automated Classification of Pulmonary Nodules through a Retrospective Analysis of Conventional CT and Two-phase PET Images in Patients Undergoing Biopsy. Teramoto, A., Tsujimoto, M., Inoue, T., Tsukamoto, T., Imaizumi, K.,Toyama, H., Saito, K., and Fujita, H. Asia Ocean J Nucl Med Biol 7, 29-37 (2019)

Decline of Plasma Concentrations of Interleukin-18 in Severely Malnourished Patients with Anorexia Nervosa: Exploratory Analysis. Tanaka, S., Oya-Ito, T., Murakami, Y., Saito, K., Furuta, S., Yu,Y., Imaeda, M., Kunimoto, S., and Ozaki, N. Nutrients 11(3), 540 (2019)

Automated Pulmonary Nodule Classification in Computed Tomography Images Using a Deep Convolutional Neural Network Trained by Generative Adversarial Networks. Onishi, Y., Teramoto, A., Tsujimoto, M., Tsukamoto, T., Saito, K.,Toyama, H., Imaizumi, K., and Fujita, H. Biomed Res Int 6051939 (2019)

Alteration of specific cytokine expression patterns in patients with breast cancer. Kawaguchi, K., Sakurai, M., Yamamoto, Y., Suzuki, E., Tsuda, M.,Kataoka, T. R., Hirata, M., Nishie, M., Nojiri, T., Kumazoe, M., Saito, K.,and Toi, M. Sci Rep 9, 2924 (2019)

Linking phencyclidine intoxication to the tryptophan-kynurenine pathway: Therapeutic implications for schizophrenia. Fujigaki, H., Mouri, A., Yamamoto, Y., Nabeshima, T., and Saito, K. Neurochem Int 125, 1-6(2019)

Excess maternal fructose consumption impairs hippocampal function in offspring via epigenetic modification of BDNF promoter. Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K., Hashimoto, S.,and Ohashi, K. FASEB J 32, 2549-2562 (2018)

Lipopolysaccharide shock reveals the immune function of indoleamine2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling. Yamamoto, Y., Yamasuge, W., Imai, S., Kunisawa, K., Hoshi, M., Fujigaki, H., Mouri, A., Nabeshima, T., and Saito, K. Sci Rep 8, 15917 (2018)

Sobue, A., Ito, N., Nagai, T., Shan, W., Hada, K., Nakajima, A.,Murakami, Y., Mouri, A., Yamamoto, Y., Nabeshima, T., Saito, K., and Yamada,K. Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes. Glia 66(5), 1034-105224(2018)

IL-6 knockout mice are protected from cocaine-induced kindling behaviors;possible involvement of JAK2/STAT3 and PACAP signalings. Mai, H. N., Chung, Y. H., Shin, E. J., Sharma, N., Jeong, J. H.,Jang, C. G., Saito, K., Nabeshima, T., Reglodi, D., and Kim, H. C. Food Chem Toxicol 116, 249-263 (2018)

Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice. Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K. Lipids Health Dis. 6(1), 106 (2017)

Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas. Yamamoto Y, Goto N, Takemura M, Yamasuge W, Yabe K, Takami T,Miyazaki T, Takeuchi T, Shiraki M, Shimizu M, Adachi S, Saito K, Shibata Y, Nakamura N, Hara T, Serrero G, Saito K, Tsurumi H Clin Chim Acta. 473, 139-146 (2017)

Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder. Kimura A, Takemura M, Saito K, Serrero G, Yoshikura N, Hayashi Y,Inuzuka T. J Neuroimmunol. 305, 175-181 (2017)

Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Tashiro T, Murakami Y, Mouri A, Imamura Y, Nabeshima T, Yamamoto Y,Saito K. Behav Brain Res 317, 279-285 (2017)

Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified. Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H. Hematol Oncol 35(4), 637-644 (2017)

Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice. Kubo H, Hoshi M, Mouri A, Tashita C, Yamamoto Y, Nabeshima T, Saito K. Immunol Lett. 181, 94-100 (2017)

Association between naturally occurring anti-amyloid β autoantibodies and medial temporal lobe atrophy in Alzheimer's disease. Kimura A, Takemura M, Saito K, Yoshikura N, Hayashi Y, Inuzuka T. J Neurol Neurosurg Psychiatry, 88(2), 126-131 (2017)

Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues., Ohta Y, Kubo H, Yashiro K, Ohashi K, Tsuzuki Y, Wada N, Yamamoto Y, Saito K. J Physiol Sci , 67(3), 361-372 (2017)

L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences. Fujigaki H, Yamamoto Y, Saito K, Neuropharmacol 112(Pt B), 264-274 (2017)

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K. Sci Rep 6, 29920 (2016)

he Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis. Shibata Y, Hara T, Nagano J, Nakamura N, Ohno T, Ninomiya S, Ito H, Tanaka T, Saito K, Seishima M, Shimizu M, Moriwaki H, Tsurumi H. PloS One 11(1), e0146279 (2016)

The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice. Ogiso H, Ito H, Ando T, Arioka Y, Kanbe A, Ando K, Ishikawa T, Saito K, Hara A, Moriwaki H, Shimizu M, Seishima M. PloS One 11(9), e0162183 (2016)

High serum concentration of L-kynurenine predicts unfavorable outcomes in patients with acute myeloid leukemia. Mabuchi R, Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Kitagawa J, Kanemura N, Goto N, Shimizu M, Ito H, Yamamoto Y, Saito K, Moriwaki H, Tsurumi H. Leuk Lymphoma 57(1), 92-98 (2016)

Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia. Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Nannya Y, Shimizu M, Ito H, Saito K, Tsurumi H. Leuk Lymphoma.57(9), 2208-2211(2016)

Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S. Mol Cell Biol. 36(6), 954-64 (2016)

Early microlesion of viral encephalitis confirmed by galectin-3 expression after a virus inoculation. Kobayashi K, Niwa M, Hoshi M, Saito K, Hisamatsu K, Hatano Y, Tomita H, Miyazaki T, Hara A. Neurosci Let 592, 107-112 (2015)

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model. Ito H, Ando T, Arioka Y, Saito K, Seishima M. Immunology 144(4) 621-630 (2015)

Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics. Fukuno K, Hara T, Tsurumi H, Shibata Y, Mabuchi R, Nakamura N, Kitagawa J, Shimizu M, Ito H, Saito K, Moriwaki H. Leuk Lymphoma. 56(5), 1398-1405 (2015)

Inhibition of indoleamine 2,3-dioxygenase activity accelerates skin wound healing.　Ito H, Ando T, Ogiso H, Arioka Y, Saito K, Seishima M. Biomaterials 53 , 221-228 (2015)

Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice. Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Ando T, Ito H, Hatano Y, Tomita H, Kuno T, Saito K, Seishima M, Hara A. Cancer Sci. 106(8), 1008-1015 (2015)

Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.Nakamura N, Hara T, Shimizu M, Mabuchi R, Nagano J, Ohno T, Kochi T, Kubota M, Shirakami Y, Goto N, Ito H, Saito K, Tanaka T, Moriwaki H, Tsurumi H. Int J Hematol , 102(3), 327-334(2015)

Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity: galanal is a novel, competitive inhibitor of the enzyme. Yamamoto R, Yamamoto Y, Imai S, Fukutomi R, Ozawa Y, Abe M, Matuo Y, Saito K. PLoS One. 9(2), e88789 (2014)

Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis. Yamamoto Y, Takemura M, Serrero G, Hayashi J, Yue B, Tsuboi A, Kubo H, Mitsuhashi T, Mannami K, Sato M, Matsunami H, Matuo Y, Saito K. Inflammation. 37(5), 1806-1813 (2014)

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y. Gene Ther. 21(9), 794-801 (2014)

Blockade of Indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Hoshi M, Osawa Y, Ito H, Ohtaki H, Ando T, Takamatsu M, Hara A, Saito K, Seishima M. Infect Immun. 82(11), 4487–4495 (2014)

Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M. Biochim Biophys Acta. 42(9) , 1464-1471(2014）

Induction of hepatitis B virus surface antigen-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity.Ito H, Ando T, Ando K, Ishikawa T, Saito K, Moriwaki H, Seishima M. Immunology.142(4), 614-623 (2014)

Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2. Kawasoe M, Yamamoto Y, Okawa K, Funato T, Takeda M, Hara T, Tsurumi H, Moriwaki H, Arioka Y, Takemura M, Matsunami H, Markey SP, Saito K. Exp Hematol. 41(7), 597-603.e2（2013）

Indoleamine 2,3-dioxygenase 1 modulates the immuneresponse; the new therapeutic targets of this drug. Yamamoto Y, Murakami Y, Hoshi M, Saito K. Nihon Yakurigaku Zasshi. 42(2), 85-88 (2013). Review.

先制医療を実現するためのバイオバンク(学会抄録)　齋藤邦明　日本臨床検査医学会誌 64(4), 445-450 (2016)

先制医療への挑戦　—バイオマーカー開発に求められる方向性—：先制医療に必要なバイオリソース/データバンク(総説)　松尾雄志, 桜井雅史, , 齋藤邦明. 臨床化学43(4) , 302-312 (2014)

Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases.（総説） Mediators Inflamm. Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K. オンラインジャーナル, 391984 (2013)

免疫調節因子Indoleamine 2,3-dioxygenase (IDO)1:創薬のターゲット分子として（総説）　山本康子, 村上由希, 星雅人, 齋藤邦明日本薬理学雑誌142, 85〜88 (2013)