〈2013年以降抜粋〉



Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified. Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H. Hematol Oncol (In press)


Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice. Kubo H, Hoshi M, Matsumoto T, Irie M, Oura S, Tsutsumi H, Hata Y, Yamamoto Y, Saito K. Lipids Health Dis. 6(1), 106 (2017)


Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice. Kubo H, Hoshi M, Mouri A, Tashita C, Yamamoto Y, Nabeshima T, Saito K. Immunol Lett. 181, 94-100 (2017)


Association between naturally occurring anti-amyloid β autoantibodies and medial temporal lobe atrophy in Alzheimer's disease. Kimura A, Takemura M, Saito K, Yoshikura N, Hayashi Y, Inuzuka T. J Neurol Neurosurg Psychiatry, 88(2), 126-131 ( 2017)


Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues., Ohta Y, Kubo H, Yashiro K, Ohashi K, Tsuzuki Y, Wada N, Yamamoto Y, Saito K. J Physiol Sci , 67(3), 361-372 (2017)


L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences. Fujigaki H, Yamamoto Y, Saito K, Neuropharmacol 112(Pt B), 264-274 (2017)


Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Tashiro T, Murakami Y, Mouri A, Imamura Y, Nabeshima T, Yamamoto Y, Saito K. Behav Brain Res. 317, 279-285 (2016)


Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1. Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K. Sci Rep 6, 29920 (2016)


The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis. Shibata Y, Hara T, Nagano J, Nakamura N, Ohno T, Ninomiya S, Ito H, Tanaka T, Saito K, Seishima M, Shimizu M, Moriwaki H, Tsurumi H. PloS One 11(1), e0146279 (2016)


The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice. Ogiso H, Ito H, Ando T, Arioka Y, Kanbe A, Ando K, Ishikawa T, Saito K, Hara A, Moriwaki H, Shimizu M, Seishima M. PloS One 11(9), e0162183 (2016)


High serum concentration of L-kynurenine predicts unfavorable outcomes in patients with acute myeloid leukemia. Mabuchi R, Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Kitagawa J, Kanemura N, Goto N, Shimizu M, Ito H, Yamamoto Y, Saito K, Moriwaki H, Tsurumi H. Leuk Lymphoma 57(1), 92-98 (2016)>


Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia. Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Nannya Y, Shimizu M, Ito H, Saito K, Tsurumi H. Leuk Lymphoma.57(9), 2208-2211(2016)


Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S. Mol Cell Biol. 36(6), 954-64 (2016)


Early microlesion of viral encephalitis confirmed by galectin-3 expression after a virus inoculation. Kobayashi K, Niwa M, Hoshi M, Saito K, Hisamatsu K, Hatano Y, Tomita H, Miyazaki T, Hara A. Neurosci Let 592, 107-112 (2015)


Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model. Ito H, Ando T, Arioka Y, Saito K, Seishima M. Immunology 144(4) 621-630 (2015)


Expression of indoleamine 2,3-dioxygenase in leukemic cells indicates an unfavorable prognosis in acute myeloid leukemia patients with intermediate-risk cytogenetics. Fukuno K, Hara T, Tsurumi H, Shibata Y, Mabuchi R, Nakamura N, Kitagawa J, Shimizu M, Ito H, Saito K, Moriwaki H. Leuk Lymphoma. 56(5), 1398-1405 (2015)


Inhibition of indoleamine 2,3-dioxygenase activity accelerates skin wound healing. Ito H, Ando T, Ogiso H, Arioka Y, Saito K, Seishima M. Biomaterials 53 , 221-228 (2015)


Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice. Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Ando T, Ito H, Hatano Y, Tomita H, Kuno T, Saito K, Seishima M, Hara A. Cancer Sci. 106(8), 1008-1015 (2015)


Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.Nakamura N, Hara T, Shimizu M, Mabuchi R, Nagano J, Ohno T, Kochi T, Kubota M, Shirakami Y, Goto N, Ito H, Saito K, Tanaka T, Moriwaki H, Tsurumi H. Int J Hematol , 102(3), 327-334(2015)


Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity: galanal is a novel, competitive inhibitor of the enzyme. Yamamoto R, Yamamoto Y, Imai S, Fukutomi R, Ozawa Y, Abe M, Matuo Y, Saito K. PLoS One. 9(2), e88789 (2014)


Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis. Yamamoto Y, Takemura M, Serrero G, Hayashi J, Yue B, Tsuboi A, Kubo H, Mitsuhashi T, Mannami K, Sato M, Matsunami H, Matuo Y, Saito K. Inflammation. 37(5), 1806-1813 (2014)


Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. Watcharanurak K, Zang L, Nishikawa M, Yoshinaga K, Yamamoto Y, Takahashi Y, Ando M, Saito K, Watanabe Y, Takakura Y. Gene Ther. 21(9), 794-801 (2014)


Blockade of Indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells. Hoshi M, Osawa Y, Ito H, Ohtaki H, Ando T, Takamatsu M, Hara A, Saito K, Seishima M. Infect Immun. 82(11), 4487–4495 (2014)


Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M. Biochim Biophys Acta. 42(9) , 1464-1471(2014)


Induction of hepatitis B virus surface antigen-specific cytotoxic T lymphocytes can be up-regulated by the inhibition of indoleamine 2, 3-dioxygenase activity.Ito H, Ando T, Ando K, Ishikawa T, Saito K, Moriwaki H, Seishima M. Immunology.142(4), 614-623 (2014)


Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2. Kawasoe M, Yamamoto Y, Okawa K, Funato T, Takeda M, Hara T, Tsurumi H, Moriwaki H, Arioka Y, Takemura M, Matsunami H, Markey SP, Saito K. Exp Hematol. 41(7), 597-603.e2(2013)


Indoleamine 2,3-dioxygenase 1 modulates the immuneresponse; the new therapeutic targets of this drug. Yamamoto Y, Murakami Y, Hoshi M, Saito K. Nihon Yakurigaku Zasshi. 42(2), 85-88 (2013). Review.


先制医療を実現するためのバイオバンク(学会抄録) 齋藤邦明 日本臨床検査医学会誌 64(4), 445-450 (2016)


先制医療への挑戦 —バイオマーカー開発に求められる方向性—:先制医療に必要なバイオリソース/データバンク(総説) 松尾雄志, 桜井雅史, , 齋藤邦明. 臨床化学43(4) , 302-312 (2014)


Remarkable role of indoleamine 2,3-dioxygenase and tryptophan metabolites in infectious diseases: potential role in macrophage-mediated inflammatory diseases.(総説) Mediators Inflamm. Murakami Y, Hoshi M, Imamura Y, Arioka Y, Yamamoto Y, Saito K. オンラインジャーナル, 391984 (2013)


免疫調節因子Indoleamine 2,3-dioxygenase (IDO)1:創薬のターゲット分子として(総説) 山本康子, 村上由希, 星雅人, 齋藤邦明 日本薬理学雑誌142, 85〜88 (2013)